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Post-COVID-19 Syndrome Clinical Manifestations: A Systematic Review

Muhammad Abdel-Gawad1, Mariam S Zaghloul2, Sherief Abd-Elsalam3

  • 1Department of Hepatology, Gastroenterology and Infectious Diseases, Al-Azhar University, Assiut, Egypt.

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
|March 29, 2022
PubMed

Insights

Many COVID-19 survivors experience long-term health issues, with 35% to 90.5% reporting persistent symptoms. Common post-COVID conditions include fatigue, shortness of breath, and neuropsychological disorders.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Clinical Medicine

Background:

  • Coronavirus disease-2019 (COVID-19) is a global pandemic with significant mortality.
  • Recovered patients frequently report persistent multisystem manifestations.
  • These long-term effects impact various organs and systems.

Approach:

  • A systematic review was conducted to determine the prevalence of post-COVID-19 manifestations.
  • Extensive literature searches were performed across multiple major databases.
  • Data were extracted and synthesized by two independent reviewers following established protocols.

Key Points:

  • The overall prevalence of post-COVID-19 manifestations ranged widely from 35% to 90.5%.
  • Fatigue, dyspnea (shortness of breath), neuropsychological disorders, and pain were the most frequently reported symptoms.
  • The findings highlight the significant burden of long COVID on patient recovery.

Conclusions:

  • A substantial percentage of COVID-19 survivors experience a diverse array of persistent clinical symptoms.
  • Fatigue, dyspnea, neuropsychological issues, and pain are the most common sequelae.
  • This underscores the need for ongoing research and clinical management strategies for post-COVID conditions.
Abstract

Keywords:
COVID-19SARS-CoV-2corona virusnovel corona viruspandemicpersistence post COVIDpost COVID

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