Enigma of COVID-19: is "multisystem inflammatory syndrome in adults" (MIS-A) predictable?
Istemi Serin1, Nagehan Didem Sari2, Murat Gunaltili3
1Department of Hematology, Istanbul Training and Research Hospital, University of Health Sciences, Org.Nafiz GURMAN Cad. Fatih, 34098, Istanbul, Turkey. serinistemi@hotmail.com.
Background:
Severe inflammation and one or more extrapulmonary organ dysfunctions have been reported and this clinical picture is defined as "multisystem inflammatory syndrome in adults" (MIS-A) in severe coronavirus disease-2019 (COVID-19). We aimed to determine the effect of LDH/lymphocyte ratio (LLR) on the development of MIS-A.
Methods:
The data of 2333 patients were retrospectively analyzed.
Results:
MIS-A rate was found to be 9.9% and MIS-A related mortality was 35.3%. LRR level above 0.24 was found to predict MIS-A development with 70% sensitivity and 65.2% specificity. The risk of MIS-A development was found to be 3.64 times higher in those with LRR levels above 0.24 compared to those with 0.24 and below. In patients with MIS-A, LRR level above 0.32 predicts mortality with 78% sensitivity and 70% specificity.
Conclusions:
Early detection of MIS-A with high sensitivity and specificity in a practical ratio is very important in terms new studies.
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