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Identification of the Genes Involved in Stomatal Development via Epidermal Phenotype Scoring
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Dynamic evolution of small signalling peptide compensation in plant stem cell control
Choon-Tak Kwon1,2, Lingli Tang3,4, Xingang Wang1
1School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA.
Nature Plants
|March 29, 2022
Summary
Gene duplications drive plant evolution, creating compensating gene pairs. We show how these interactions change, impacting traits like floral development, due to genetic variation over short evolutionary times.
Area of Science:
- Plant genetics
- Evolutionary genomics
- Molecular biology
Background:
- Gene duplications are crucial for plant genome evolution and phenotypic diversity.
- Gene compensation, a form of paralogue interaction, is common, but its evolutionary dynamics remain unclear.
- Understanding how compensation evolves is key to explaining genetic interactions and phenotypic variation.
Purpose of the Study:
- To investigate the evolution of compensating paralogues in the Solanaceae family.
- To understand how genetic variation affects gene compensation and phenotypic outcomes.
- To explore the impact of paralogue evolution on traits like floral development.
Main Methods:
- Genomic analysis across the Solanaceae family.
- Genome editing techniques.
- Cross-species transgenic complementation analyses.
Main Results:
- Compensation for CLAVATA3 (CLV3) mutations varies significantly across Solanaceae species, with petunia and groundcherry showing potent suppression.
- Tomato exhibits partial compensation due to a single amino acid change and cis-regulatory variation limiting paralogue upregulation.
- Tobacco has lost the compensating paralogue, leading to extreme clv3 phenotypes.
Conclusions:
- Genetic interactions, such as gene compensation, are dynamically remodeled following gene duplications.
- Paralogue evolution can rapidly alter phenotypic variation from both natural and engineered mutations.
- This study provides insights into the rapid evolution of genetic interactions and their impact on plant phenotypes.
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