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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Levels of Health Promotion and Illness Prevention01:26

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Sep 28, 2025

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
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Metastasis prevention: targeting causes and roots.

A A Schegoleva1, A A Khozyainova1, T S Gerashchenko1

  • 1Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str. 5, 634009, Tomsk, Russia.

Clinical & Experimental Metastasis
|March 29, 2022
PubMed
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Preventing cancer metastasis, the spread of tumor cells, is crucial for survival. This review explores targeting metastasis causes and roots, highlighting challenges and opportunities for effective anticancer therapies.

Keywords:
CancerMetastasisMetastatic cascadePreventionTherapy

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Area of Science:

  • Oncology
  • Cancer Metastasis Research

Background:

  • Metastasis, the spread of tumor cells, is the primary cause of cancer-related mortality.
  • Effective anticancer therapies must prioritize the prevention of metastatic disease.

Purpose of the Study:

  • To review current approaches targeting the causes and roots of metastasis.
  • To discuss challenges in metastasis prevention and suggest future directions.
  • To emphasize the importance of clinical evaluation for antimetastatic agents.

Main Methods:

  • Review of literature on targeting metastasis.
  • Discussion of therapeutic strategies for metastasis prevention.
  • Analysis of challenges and opportunities in antimetastatic drug development.

Main Results:

  • Identified key targets including hypoxia, metabolic changes, tumor microenvironment, angiogenesis, epithelial-mesenchymal transition, migration, and invasion.
  • Highlighted limitations of current antimetastatic approaches.
  • Proposed strategies to overcome existing challenges.

Conclusions:

  • Targeting metastasis causes and roots is essential for improving cancer patient outcomes.
  • Clinical evaluation of antimetastatic agents, particularly in early-stage cancers, is critical.
  • Further research is needed for identifying metastatic seeds and developing effective eradication therapies.