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Metastasis prevention: targeting causes and roots

A A Schegoleva1, A A Khozyainova1, T S Gerashchenko1

  • 1Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str. 5, 634009, Tomsk, Russia.

Clinical & Experimental Metastasis
|March 29, 2022
PubMed

Insights

Preventing cancer metastasis, the spread of tumor cells, is crucial for survival. This review explores targeting metastasis causes and roots, highlighting challenges and opportunities for effective anticancer therapies.

Area of Science:

  • Oncology
  • Cancer Metastasis Research

Background:

  • Metastasis, the spread of tumor cells, is the primary cause of cancer-related mortality.
  • Effective anticancer therapies must prioritize the prevention of metastatic disease.

Purpose of the Study:

  • To review current approaches targeting the causes and roots of metastasis.
  • To discuss challenges in metastasis prevention and suggest future directions.
  • To emphasize the importance of clinical evaluation for antimetastatic agents.

Main Methods:

  • Review of literature on targeting metastasis.
  • Discussion of therapeutic strategies for metastasis prevention.
  • Analysis of challenges and opportunities in antimetastatic drug development.

Main Results:

  • Identified key targets including hypoxia, metabolic changes, tumor microenvironment, angiogenesis, epithelial-mesenchymal transition, migration, and invasion.
  • Highlighted limitations of current antimetastatic approaches.
  • Proposed strategies to overcome existing challenges.

Conclusions:

  • Targeting metastasis causes and roots is essential for improving cancer patient outcomes.
  • Clinical evaluation of antimetastatic agents, particularly in early-stage cancers, is critical.
  • Further research is needed for identifying metastatic seeds and developing effective eradication therapies.
Keywords:
CancerMetastasisMetastatic cascadePreventionTherapy

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