Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 28, 2025

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
08:07

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

8.5K

Mandibular condyle changes in rats with unilateral masticatory function.

Enrico De Carli1, Aikaterini Lagou1, Stavros Kiliaridis1,2

  • 1Department of Orthodontics, Clinique Universitaire de Médecine Dentaire, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Orthodontics & Craniofacial Research
|March 29, 2022
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term effects of altered functional demands induced by diet consistency throughout growth on adult rat masticatory muscle fibres.

Archives of oral biology·2026
Same author

The Impact of Orthodontic Treatment on Masseter Muscle Development in Pediatric Patients: A One-Year Follow-Up Study.

Journal of clinical medicine·2025
Same author

The association of malocclusions with masseter muscle thickness based on ultrasonography measurements: a retrospective cohort study.

European journal of orthodontics·2025
Same author

Longitudinal changes in maxillary alveolar bone after molar extraction in young and adult male rats.

Archives of oral biology·2025
Same author

Effect of masticatory muscle function on the craniofacial sutures of the anterior viscerocranium in growing rats.

European journal of oral sciences·2024
Same author

The effect of occlusal loading on secondary tooth eruption: An experimental study using a rat model.

Journal of morphology·2024

Unilateral tooth loss in young rats thins the condyle's cross-sectional surface without affecting height or width during growth. Adult rats showed minimal impact from altered chewing function on condylar morphology.

Area of Science:

  • Biomedical Engineering
  • Craniofacial Biology
  • Developmental Biology

Background:

  • Asymmetric masticatory function can induce skeletal changes in the mandibular condyle, particularly in growing individuals.
  • The impact of unilateral function on condylar morphology in adult animals is less understood.
  • Understanding these adaptive processes is crucial for addressing malocclusions and tooth loss.

Purpose of the Study:

  • To investigate the three-dimensional effects of unilateral masticatory function on condylar process morphology in growing and adult rats.
  • To analyze the adaptive processes to differential condylar loading in response to induced asymmetry.
  • To compare the effects in young versus mature animal models.

Main Methods:

  • Fifty-six Wistar rats (4 and 26 weeks old) underwent unilateral maxillary molar extraction.
Keywords:
condyle morphologymandibular condylemicro-CTmolar extractionocclusal function

More Related Videos

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

905
Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

481

Related Experiment Videos

Last Updated: Sep 28, 2025

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
08:07

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

8.5K
Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

905
Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

481
  • Animals were monitored for 12 weeks post-extraction.
  • In-vivo microcomputed tomography (micro-CT) was used to assess condylar process height, base width, and cross-sectional surface.

    • Main Results:

    • Condylar process height and base width showed no significant differences between sides in either age group.
    • The cross-sectional surface of the condyle on the extraction side did not increase in young rats during growth.
    • Adult rats exhibited no significant differences in condylar morphology due to extraction.
    • Young rats had significantly smaller condylar dimensions than adult rats at baseline and showed significant growth over the study period.

    Conclusions:

    • Condylar height and base width growth are not significantly hindered by reduced occlusal function.
    • The average cross-sectional surface of the condyle is reduced in growing individuals lacking occlusal stimuli, leading to a thinner condyle.
    • The condyle of adult rats is less susceptible to adaptive changes in morphology following occlusal alterations.