Related Experiment Video
Updated: Sep 28, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.8K
Advances in targeted therapy for anaplastic thyroid carcinoma
Chenhong Qian1,2, Liehao Jiang2,3, Shiying Xu2,4
11. Graduate School, Bengbu Medical College, Bengbu 233030, Anhui Province, China.
Summary
Anaplastic thyroid carcinoma (ATC) lacks effective treatments. Targeted therapies like lenvatinib, dabrafenib with trametinib, and pembrolizumab show promise for managing this aggressive cancer.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid malignancy with a poor prognosis.
- Current treatment options for ATC are limited, necessitating the exploration of novel therapeutic strategies.
Purpose of the Study:
- To review the current research progress on targeted drugs for anaplastic thyroid carcinoma (ATC).
- To highlight the potential of molecular targeted therapy in improving outcomes for ATC patients.
Main Methods:
- Literature review of clinical trials and research studies on targeted therapies for ATC.
- Analysis of the efficacy and mechanisms of action of various targeted agents.
Main Results:
- Tyrosine kinase inhibitor lenvatinib demonstrates potential efficacy in clinical trials.
- BRAF inhibitor dabrafenib in combination with MEK inhibitor trametinib is a preferred treatment for BRAF-positive ATC.
- Immune checkpoint inhibitor pembrolizumab shows promise for ATC with high tumor mutational load or PD-L1 expression.
Conclusions:
- Targeted therapies offer new hope for anaplastic thyroid carcinoma treatment.
- Ongoing research into agents like mTOR inhibitors, PPARγ agonists, and novel vascular blockers may provide future treatment avenues.
Related Concept Videos
02:57Targeted Cancer Therapies
7.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.9K
01:27Tumor Immunotherapy
693
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
693
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K