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Microfluidics in Assessing Platelet Function
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Comparison of Factors Associated with Inflammation, Thrombosis, and Platelet Reactivity as well as Turnover between

Lior Fortis1,2, Ella Yehud1,2, Ziv Sevilya3

  • 1Department of Cardiology, Assuta Ashdod University Hospital, Ashdod, Israel.

The Israel Medical Association Journal : IMAJ
|March 29, 2022
PubMed

Insights

Patients with a high CHA2DS2-VASc score in sinus rhythm show increased inflammation and soluble P-selectin, suggesting a link to higher cardiovascular event rates. This highlights potential biomarkers for risk stratification.

Area of Science:

  • Cardiovascular Medicine
  • Thrombosis Research
  • Inflammation Biology

Background:

  • The CHA2DS2-VASc score predicts thromboembolism and mortality in atrial fibrillation (AF) and sinus rhythm (SR).
  • Understanding risk factors beyond traditional scoring is crucial for cardiovascular event prevention.

Purpose of the Study:

  • To compare inflammation, thrombosis, and platelet markers in SR patients with high versus low CHA2DS2-VASc scores.
  • To identify specific biological factors associated with elevated cardiovascular risk in SR.

Main Methods:

  • Consecutive SR patients without AF history were enrolled.
  • Blood samples analyzed for neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), immature platelet fraction (IPF), CD40 ligand, soluble P-selectin (sP-selectin), and E-selectin.
  • Measurements performed using ELISA and autoanalyzer.

Main Results:

  • 108 patients included; 52 had high CHA2DS2-VASc scores (≥2 male, ≥3 female).
  • High-score group exhibited elevated CRP (P < 0.001) and NLR (P = 0.001).
  • Significantly higher sP-selectin levels observed in the high-score group (P = 0.041).

Conclusions:

  • Elevated CHA2DS2-VASc scores in SR are associated with increased inflammatory markers (CRP, NLR) and sP-selectin.
  • These findings may elucidate the mechanism behind increased adverse cardiovascular events in high-risk SR patients.
  • sP-selectin and inflammatory markers could serve as potential biomarkers for risk stratification in SR.
Abstract

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