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New Adjunct Therapy for Elevated Lipid Levels

Diane S Aschenbrenner1

  • 1Diane S. Aschenbrenner is a former member of the faculty at Notre Dame of Maryland University and the Johns Hopkins University School of Nursing. She coordinates Drug Watch:diane.aschenbrenner@gmail.com .

The American Journal of Nursing
|March 29, 2022
PubMed

Insights

Inclisiran (Leqvio) is a new injectable treatment for adults with high cholesterol. It is approved for patients with familial hypercholesterolemia or atherosclerotic cardiovascular disease who need further LDL cholesterol reduction.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Familial hypercholesterolemia and atherosclerotic cardiovascular disease increase cardiovascular risk.
  • Elevated low-density lipoprotein cholesterol (LDL-C) is a primary driver of cardiovascular disease.
  • Maximal statin therapy does not adequately reduce LDL-C in all patients.

Purpose of the Study:

  • To introduce Inclisiran (Leqvio) as an approved adjunct therapy.
  • To highlight its role in managing LDL-C in specific adult patient populations.

Main Methods:

  • Inclisiran is administered subcutaneously.
  • Treatment is intended as an adjunct to diet and statin therapy.

Main Results:

  • Inclisiran provides additional reduction in LDL-C.
  • It is approved for adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease.

Conclusions:

  • Inclisiran offers a new therapeutic option for patients requiring further LDL-C lowering.
  • The subcutaneous administration by a healthcare provider ensures proper delivery.

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