Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

12.0K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
12.0K
Protein Networks02:26

Protein Networks

4.1K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.1K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

11.6K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.6K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

3.9K
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SpliceSelectNet: a hierarchical Transformer-based deep learning model for splice site prediction.

Nucleic acids research·2026
Same author

A dataset of 1.2 million molecules with DFT-level quantum chemical annotations for molecular representation learning.

Communications chemistry·2026
Same author

Toward Graph-Based Decoding of Tumor Evolution: Spatial Inference of Copy Number Variations.

Diagnostics (Basel, Switzerland)·2025
Same author

Establishing the Asia & Pacific Bioinformatics Joint Congress: a historic milestone in regional bioinformatics collaboration.

Briefings in bioinformatics·2025
Same author

Multi-view gene panel characterization for spatially resolved omics.

Briefings in bioinformatics·2025
Same author

A message passing framework for precise cell state identification with scClassify2.

Genome biology·2025
Same journal

STED: flexible cross-modal topic modeling infers cell-type-specific regulatory landscapes from bulk epigenomics.

Briefings in bioinformatics·2026
Same journal

A knowledge-guided deep learning framework for quantitative nucleic acid testing.

Briefings in bioinformatics·2026
Same journal

Optimal transport for label transfer in single-cell multi-omics integration.

Briefings in bioinformatics·2026
Same journal

Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.

Briefings in bioinformatics·2026
Same journal

Evaluating completeness, coherence, and consistency of genome-scale function annotations.

Briefings in bioinformatics·2026
Same journal

Transformers for single-cell RNA sequencing: a survey.

Briefings in bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Sep 28, 2025

Deep Neural Networks for Image-Based Dietary Assessment
13:19

Deep Neural Networks for Image-Based Dietary Assessment

Published on: March 13, 2021

9.4K

Protein design via deep learning.

Wenze Ding1,2,3,4, Kenta Nakai5, Haipeng Gong3,4

  • 1School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing 210044, China.

Briefings in Bioinformatics
|March 29, 2022
PubMed
Summary
This summary is machine-generated.

Deep learning is revolutionizing de novo protein design, enabling the creation of novel proteins for nanotechnology and biomedicine. This review explores advances in deep learning for protein design, highlighting future opportunities.

Keywords:
deep learningdeep reinforcement learningprotein designprotein sequenceprotein structure

More Related Videos

A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
09:34

A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

Published on: September 25, 2021

4.1K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.2K

Related Experiment Videos

Last Updated: Sep 28, 2025

Deep Neural Networks for Image-Based Dietary Assessment
13:19

Deep Neural Networks for Image-Based Dietary Assessment

Published on: March 13, 2021

9.4K
A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
09:34

A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

Published on: September 25, 2021

4.1K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.2K

Area of Science:

  • Biotechnology
  • Computational Biology
  • Protein Engineering

Background:

  • Proteins with specific functions are crucial for nanotechnology and biomedicine.
  • De novo protein design allows the creation of novel proteins from scratch.
  • Deep learning has recently emerged as a transformative approach in protein design.

Purpose of the Study:

  • To review current advances in deep learning-based de novo protein design.
  • To compare deep learning methods with traditional knowledge-based approaches.
  • To discuss future perspectives in protein design.

Main Methods:

  • Review of recent literature on deep learning applications in protein design.
  • Analysis of structure-based protein design and direct sequence design using deep learning.
  • Highlighting applications of deep reinforcement learning in protein design.

Main Results:

  • Deep learning methods offer novel capabilities compared to conventional approaches.
  • Significant progress has been made in structure-based and sequence-based protein design.
  • Deep reinforcement learning shows promise for advanced protein design tasks.

Conclusions:

  • Deep learning represents a promising future direction for de novo protein design.
  • Further research is needed to address challenges and explore opportunities in the field.
  • Advances in protein design have broad implications for science and technology.