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Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial

Johan S Bundgaard1, Kasper Iversen2,3, Mia Pries-Heje4

  • 1Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark. johan.skov.bundgaard.01@regionh.dk.

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
|March 29, 2022
PubMed

Insights

Patients with endocarditis reporting poor health status had a threefold increased risk of long-term mortality. This finding highlights the importance of self-assessed health status in predicting outcomes for endocarditis patients.

Area of Science:

  • Cardiology
  • Clinical Research
  • Public Health

Background:

  • Self-assessed poor health status is a known mortality risk factor in cardiovascular conditions.
  • This association has not been previously studied in patients diagnosed with endocarditis.

Purpose of the Study:

  • To investigate the relationship between self-assessed health status and all-cause mortality in patients with endocarditis.
  • To determine if poor self-assessed health status predicts mortality in this specific patient population.

Main Methods:

  • A substudy of the POET endocarditis trial involving 400 patients.
  • Patients categorized health status as poor or non-poor using a single question from the Short-Form 36 questionnaire.
  • Cox regression analysis used to examine self-assessed health status and all-cause mortality.

Main Results:

  • 266 patients (67%) completed the health status assessment; 8% reported poor health.
  • Over a median follow-up of 3.3 years, mortality was 43% in the poor health group versus 20% in the non-poor group.
  • Poor self-assessed health status was associated with a threefold increased hazard ratio for death (HR 3.4, P < 0.01).

Conclusions:

  • Self-assessed poor health status is significantly associated with a threefold increase in long-term mortality among endocarditis patients.
  • A single question on self-assessed health status can be a valuable prognostic indicator in endocarditis care.
  • Findings underscore the clinical relevance of subjective health perception in infectious endocarditis outcomes.
Abstract

Keywords:
Cardiovascular diseaseEndocarditisHealth statusRisk factor and mortality

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