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Updated: Jul 26, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
GENIGMA: an app to map the 3D genome of cancer cell lines through extreme citizen science
1FEBS Letters Editorial Office, Heidelberg University Biochemistry Center, Germany.
Abstract:
In this Scientists' Forum article, we present a new app, GENIGMA, launched by structural genomics specialist Marc A. Marti-Renom and his team, aimed at mapping the 3D genome of cancer cell lines. GENIGMA is a digital game, which was designed and tested through a co-creation process with citizens. Finally, by playing the game, citizens produce data, reaching beyond the capacity of artificial intelligence. This is an exceptional experiment of extreme citizen science, which broadens the implications of open science.
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