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Updated: Sep 28, 2025

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
Published on: October 16, 2019
Synchronous spiking of cerebellar Purkinje cells during control of movements
Ehsan Sedaghat-Nejad1, Jay S Pi1, Paul Hage1
1Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Abstract:
SignificanceThe information that one region of the brain transmits to another is usually viewed through the lens of firing rates. However, if the output neurons could vary the timing of their spikes, then, through synchronization, they would spotlight information that may be critical for control of behavior. Here we report that, in the cerebellum, Purkinje cell populations that share a preference for error convey, to the nucleus, when to decelerate the movement, by reducing their firing rates and temporally synchronizing the remaining spikes.
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