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Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Sep 28, 2025

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Uveitis-Glaucoma-Hyphema Syndrome Following iStent Implantation.

Adam Siedlecki¹, Bhumi Kinariwala², Sandra Sieminski³

¹Department of Ophthalmology, University at Buffalo, Buffalo, New York, USA.

Case Reports in Ophthalmology

|March 30, 2022

Summary

Minimally invasive glaucoma surgery (MIGS) using iStent can cause rare complications like recurrent hyphema. Removing the iStent resolved symptoms in one patient, highlighting potential risks and management strategies.

Keywords:

Glaucoma Implant removal Minimally invasive glaucoma surgery Recurrent hyphema Uveitis-glaucoma-hyphema syndrome iStent

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Area of Science:

Ophthalmology
Glaucoma Surgery
Medical Device Complications

Background:

Minimally invasive glaucoma surgery (MIGS) offers a safer alternative to traditional glaucoma procedures.
iStent implantation is a common MIGS technique used concurrently with cataract surgery.

Observation:

A patient developed recurrent spontaneous microhyphema and inflammation post-iStent implantation and cataract surgery.
Exfoliation syndrome was noted, potentially causing zonular weakness and anterior lens-iris diaphragm movement.
Extensive workup ruled out conventional causes for recurrent hyphema.

Findings:

iStent-iris interaction was suspected as the cause of microtrauma, leading to recurrent hyphema.
iStent removal and OMNI canaloplasty resulted in complete symptom resolution without hyphema recurrence.
This case highlights a potential complication of iStent use in patients with specific anatomical predispositions.

Implications:

MIGS devices, including iStents, may have rare but significant complications.
Careful patient selection and monitoring are crucial for MIGS procedures.
iStent explantation can be an effective treatment for specific device-related complications.