Perspectives in translating microfluidic devices from laboratory prototyping into scale-up production

Area of Science:

• Biotechnology
• Medical Devices
• Manufacturing Engineering

Background:

• The microfluidic field is increasingly focused on commercializing laboratory research.
• Significant gaps exist between academic research and industrial production, particularly in scaling up microfluidic devices.
• Successful commercialization hinges on bridging these gaps from laboratory prototyping to industrial scale-up.

Purpose of the Study:

• To provide an understanding of the microfluidic cartridge manufacturing process chain.
• To highlight the critical aspects of scale-up production for commercial microfluidic cartridges.
• To offer actionable suggestions for scientists to improve manufacturability and commercialize innovations.

Main Methods:

• The study is a perspective based on collaborative experience with diverse stakeholders (biologists, engineers, diagnostic specialists, manufacturers).
• Analysis of the manufacturing process chain from concept development through laboratory prototyping to scale-up production.
• Identification of key challenges and areas for improvement in microfluidic cartridge development.

Main Results:

• Commercialization of microfluidic devices requires a structured approach to manufacturing.
• Scale-up production presents unique hurdles distinct from laboratory prototyping.
• Collaboration across disciplines is essential for successful translation.

Conclusions:

• Four key areas are suggested for improving microfluidic cartridge manufacturability: design for manufacturing, professional involvement, material selection, and standardization.
• These suggestions aim to facilitate the transition of laboratory innovations into pre-clinical, clinical, and mass production.
• Addressing these aspects can enhance the commercial viability of microfluidic technologies.