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Postpartum depression in maternal thyroidal changes.

Paula Michele da Silva Schmidt1, Aline Longoni1, Ricardo Tavares Pinheiro1

  • 1Center of Health Science, Postgraduate Program in Health and Behavior, Universidade Católica de Pelotas - UCPel, Pelotas, RS, 96015-560, Brazil.

Thyroid Research
|March 30, 2022
PubMed
Summary
This summary is machine-generated.

This systematic review examined postpartum depression (PPD) in women with thyroid issues. While thyroid antibodies may link to depression, conclusive evidence is still lacking.

Keywords:
Perinatal depressionPostpartum depressionPregnancyThyroidThyroid peroxidase antibodies

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Psychiatry

Background:

  • Literature suggests a potential link between thyroid antibodies and maternal depression.
  • Thyroid dysfunction is common during pregnancy and the postpartum period.

Purpose of the Study:

  • To systematically review the prevalence of postpartum depression (PPD) in women with thyroid abnormalities.
  • To explore the association between thyroid antibodies and PPD.

Main Methods:

  • Systematic review of 15 studies (case-control, cross-sectional, prospective cohort).
  • Searched four databases: PubMed, Lilacs, Scielo, and Scopus.
  • Included studies focused on the first year postpartum.

Main Results:

  • Prevalence of PPD in pregnant women with thyroid disorders ranged from 8.3% to 36.0%.
  • Cumulative incidence of self-reported depression in the first postpartum year was 6.3% in one study.
  • Positive anti-TPO antibodies are considered a potential vulnerability marker for depression by some.

Conclusions:

  • The current evidence does not allow a definitive conclusion on whether thyroid function during the pregnancy-puerperal cycle contributes to PPD development.
  • Further research is needed to clarify the role of thyroid abnormalities in PPD.