Multimodal thrombectomy device for treatment of acute deep venous thrombosis

Area of Science:

• Vascular Surgery
• Medical Device Innovation
• Thrombosis Research

Background:

• Deep vein thrombosis (DVT) is a serious condition involving blood clots in deep veins, posing risks of pulmonary embolism (PE) and death.
• Current DVT treatments have limitations in effectiveness and safety due to the inability to isolate the treatment area.
• Thousands of Americans are affected annually by DVT, incurring significant treatment costs.

Purpose of the Study:

• To develop and evaluate a novel thrombectomy device designed for sequestering deep vein thrombosis (DVT) during fragmentation and evacuation.
• To assess the safety and efficacy of this sequestered approach compared to existing thrombectomy methods.

Main Methods:

• A novel thrombectomy device was engineered to create a defined, sequestered treatment zone for DVT.
• Ex vivo thrombectomy procedures were performed using the novel device and a predicate device for comparison.
• Key outcomes measured included distal DVT embolization and impact on vein wall diameter during isovolumetric infusion and suction.

Main Results:

• The sequestered thrombectomy approach significantly reduced distal DVT embolization compared to the predicate device.
• Isovolumetric infusion and suction facilitated effective clearance of the sequestered treatment zone.
• The novel device maintained vein wall diameter without significant adverse impact during the procedure.

Conclusions:

• The novel sequestered thrombectomy device demonstrates potential for improved safety and efficacy in DVT treatment.
• This approach offers a promising solution for managing high-risk, large-volume deep vein thromboses.
• Further investigation into this innovative therapeutic strategy is warranted.