Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

766
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
766
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

500
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
500
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

234
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
234
Drug Delivery: Overview01:16

Drug Delivery: Overview

445
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
445
Drug Dependence01:17

Drug Dependence

1.2K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.2K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequence-specific targeting of VEGFA genomic DNA to inhibit tumor growth.

NPJ precision oncology·2026
Same author

Investigating the role of mimosine-induced genotoxic stress through DNA repair profiling.

Molecular therapy. Nucleic acids·2026
Same author

The impact of antisense oligonucleotide (ASO) therapeutics on the future of rare disease drug discovery.

Expert opinion on drug discovery·2026
Same author

Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates.

Molecular therapy. Nucleic acids·2026
Same author

Advances in peptide nucleic acid for targeting RNA and genomic DNA.

Cell reports. Physical science·2026

Related Experiment Video

Updated: Sep 28, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.0K

Nanoparticle delivery systems for substance use disorder.

Vishal Kasina1, Robert J Mownn1, Raman Bahal1

  • 1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|March 30, 2022
PubMed
Summary

Nanotechnology offers new ways to deliver therapies across the brain for substance use disorder (SUD). This review explores nanocarrier systems for improved brain drug delivery and future SUD treatments.

More Related Videos

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.7K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.4K

Related Experiment Videos

Last Updated: Sep 28, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.0K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.7K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.4K

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Pharmacology

Background:

  • Nanotechnology innovations are crucial for healthcare, particularly for brain diseases requiring advanced therapeutic delivery.
  • Nanoparticle systems can transport diagnostic and therapeutic agents across biological barriers to targeted cells over time.
  • Substance Use Disorder (SUD) has many identified therapeutic targets, but clinical translation is limited by challenges in brain-specific drug delivery.

Purpose of the Study:

  • To review nanotherapeutic brain delivery systems for Substance Use Disorder (SUD).
  • To evaluate potential approaches and limitations of nanocarrier-based treatments for SUD.
  • To highlight promising strategies and future directions in nanomedicine for SUD.

Main Methods:

  • Literature review of nanotechnology applications in brain disease treatment.
  • Analysis of nanocarrier capabilities for crossing biological barriers.
  • Evaluation of preclinical and clinical studies on nanotherapeutics for SUD.

Main Results:

  • Nanoparticle delivery systems show potential for targeted drug delivery to the brain.
  • Significant challenges remain in translating nanotherapeutic strategies for SUD into clinical practice.
  • Various nanocarrier strategies show promise for future SUD treatment development.

Conclusions:

  • Nanotechnology holds significant promise for overcoming brain delivery challenges in SUD.
  • Further research and development are needed to optimize nanocarrier systems for effective SUD therapies.
  • Nanomedicine offers a promising avenue for advancing treatments for brain diseases like SUD.