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The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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Veins, while chiefly responsible for circulating blood back to the heart, also function as storage vessels for blood. They house approximately 64 percent of the body's total blood volume, a feat made possible by their high capacitance—the inherent ability to expand and accommodate large volumes of blood, even under low pressure. The large diameter and thin walls of veins augment their distensibility, significantly more so than arteries, due to their classification as capacitance...
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Veins are an integral part of our circulatory system, serving as the blood vessels that transport blood from all body regions to the heart. They are a network of hollow tubes that carry blood low in oxygen from the body's cells back to the heart for reoxygenation. Veins are crucial for maintaining the body's overall fluid balance and the continuous circulation of blood.
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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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Related Experiment Video

Updated: Sep 28, 2025

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
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Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

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The vascular outsiders.

Veronica Carroll1

  • 1Senior Lecturer in Vascular Biology, Section of Cell Biology, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK. vcarroll@sgul.ac.uk.

British Journal of Cancer
|March 30, 2022
PubMed
Summary
This summary is machine-generated.

Cancers utilize vessel co-option and angiotropic extravascular migratory metastasis sequentially for tumor growth and spread, according to Lugassy et al. This perspective highlights dual mechanisms in cancer progression and metastasis.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Vessel co-option involves tumor cells hijacking existing blood vessels.
  • Angiotropic extravascular migratory metastasis describes tumor cells spreading along blood vessels outside the bloodstream.

Discussion:

  • Lugassy et al. propose a sequential model where vessel co-option precedes angiotropic metastasis.
  • This integrated mechanism offers a novel understanding of tumor progression and dissemination.

Key Insights:

  • Cancers employ a dual strategy for growth and spread.
  • Sequential activation of vessel co-option and angiotropic metastasis is a key finding.

Outlook:

  • Further research is needed to validate this sequential model.
  • Understanding these mechanisms can inform new therapeutic strategies targeting cancer metastasis.