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Published on: November 10, 2023
Severity of Illness in Bronchiolitis Amid Unusual Seasonal Pattern During the COVID-19 Pandemic
Kristen H Shanahan1,2, Michael C Monuteaux1,2, Richard G Bachur1,2
1aDivision of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts.
Insights
Recent bronchiolitis trends show differing seasonality but consistent illness severity in infants. This analysis tracked over 389,000 emergency visits across US children
Area of Science:
- Pediatric infectious diseases
- Epidemiology of respiratory infections
Background:
- Bronchiolitis is a common viral respiratory infection in infants.
- Understanding seasonal trends and illness severity is crucial for healthcare planning.
Purpose of the Study:
- To analyze recent trends in bronchiolitis at US children's hospitals.
- To compare the severity of bronchiolitis in the most recent year (Oct 2020-Sep 2021) with previous seasons.
Main Methods:
- Cross-sectional study of 389,411 emergency visits for bronchiolitis in infants <24 months.
- Data collected from 46 US children's hospitals (Oct 2016-Sep 2021).
- Logistic and Fourier Poisson regression models used to examine trends and seasonality.
Main Results:
- Median infant age with bronchiolitis was higher in Oct 2020-Sep 2021 (8 months) vs. prior seasons (6 months).
- No significant difference in hospitalization, ICU admission, or ventilation rates was observed.
- Seasonality of bronchiolitis varied significantly between the study periods (P < .001).
Conclusions:
- Despite altered seasonality, the severity of infant bronchiolitis remained consistent.
- Findings suggest that while the timing of epidemics may shift, clinical outcomes have not worsened.
Objective:
We aimed to characterize recent trends in bronchiolitis at US children's hospitals and to compare severity of illness in bronchiolitis in the most recent year to the previous seasonal epidemics.
Methods:
This is a cross-sectional study of visits for bronchiolitis in infants <24 months old from October 2016 to September 2021 at 46 US children's hospitals participating in the Pediatric Health Information Systems database. Study years were defined by 12-month periods beginning in October to account for typical winter epidemics that crossover calendar years. We used logistic and Fourier Poisson regression models to examine trends in outcomes and compare seasonality, respectively.
Results:
The study included 389 411 emergency visits for bronchiolitis. Median age of infants with bronchiolitis was higher in October 2020 to September 2021 compared to previous epidemics (8 and 6 months, respectively, P < .001) The odds of hospitalization, ICU admission, invasive mechanical ventilation, and noninvasive ventilation did not differ in October 2020 to September 2021 compared to previous epidemics from October 2016 to September 2020 (all P > .05 for unadjusted models and models adjusted for age). Seasonality varied significantly among these 2 periods (P < .001).
Conclusions:
Although the seasonality of bronchiolitis differed in October 2020 to September 2021, severity of illness in infants with bronchiolitis was consistent with previous epidemics.
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