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Metabolism of a New Dipeptide Neuroprotector in Rats
G B Kolyvanov1, P O Bochkov1, A A Litvin2
1Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Abstract:
Metabolism of a new neuroprotector GZK-111 (N-phenylacetylglycyl-L-proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotransformation are hydrolysis of the ester bond by esterases followed by degradation of the resulting metabolite, as well as reactions leading to the formation of phenylacetic acid and cycloprolylglycine that exhibits neuropsychotropic activity.
