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Updated: Sep 28, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells
Published on: December 5, 2018
Exosomes as Carriers for Drug Delivery in Cancer Therapy
Weiping Zeng1,2, Zhengbo Wen2, Honglin Chen3,4,5,6
1School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, People's Republic of China.
Abstract:
Exosomes are extracellular vesicles secreted by cells with a particle size of 30-150 nm in diameter. Exosomes can be used as natural drug carriers. The treatment of cancer with drug-loaded exosomes is an area of high interest. This review introduces the composition, function, isolation and characterization of exosomes, and briefly describes the selection of exosome donor cells and methods for drug loading. Through studies on therapies with drug-loaded exosomes in gastric cancer, lung cancer, brain cancer and other cancers, the advantages and disadvantages of drug-loaded exosomes have been analyzed.
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