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Updated: Jul 28, 2026
Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi-institutional
Kimihide Kusafuka1, Yoko Sato2, Eiji Nakatani2
1Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.
Background:
Salivary duct carcinoma (SDC) is a high-grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC.
Methods:
We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes.
Results:
The median age of the cases examined was 68 years, the most common primary site was the parotid gland (238 cases), and there was a male predominance (M/F = 5:1). Outcomes were significantly worse when the primary tumor site was the minor salivary glands (SG) than when it was the major SG. Outcomes were also significantly worse in pN(+) cases (161 cases) than in pN0 cases, particularly those with a metastatic lymph node number ≥11. The cumulative incidence of relapse and distant metastases was significantly higher in stage IV cases than in stage 0-III cases.
Conclusions:
The absolute number of lymph node metastases, higher stages, and the minor SG as the primary tumor site were identified as factors affecting the outcome of SDC.
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