Related Experiment Video
Updated: Sep 28, 2025

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
Published on: October 25, 2016
NMDA and AMPA receptor physiology and role in visceral hypersensitivity: a review
Fangli Cheng1, Lijun Du1, John J Kim2
1Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Abstract:
N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are excitatory neurotransmission receptors of the central nervous system and play vital roles in synaptic plasticity. Although not fully elucidated, visceral hypersensitivity is one of the most well-characterized pathophysiologic abnormalities of functional gastrointestinal diseases and appears to be associated with increased synaptic plasticity. In this study, we review the updated findings on the physiology of NMDARs and AMPARs and their relation to visceral hypersensitivity, which propose directions for future research in this field with evolving importance.
Related Concept Videos
Analgesia and Pain Management
Nociception
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Mechanically-gated Ion Channels
Opioid Receptors: Overview

