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Published on: September 27, 2024
Clinical factors and outcomes of malignant meningioma: a population-based study
Gui-Jun Zhang1, Xiao-Yin Liu1, Wei Wang2
1Department of Neurosurgery, West China Hospital, Sichuan University, Sichuan, China.
Objective:
We aimed to investigate prognostic factors and outcomes of malignant meningioma and to construct a nomogram model of survival.
Methods:
Patients with malignant meningioma were collected from the Surveillance, Epidemiology, and End Results database. The nomogram was developed for the 3-, 5-, and 8-year prediction of overall survival (OS) and cancer-specific survival (CSS). Harrell's concordance index (C-index) and decision curve analysis (DCA) were used to verify the predicted effect of the nomogram.
Results:
Between 1998 and 2016, 806 adult patients with histologically confirmed malignant meningioma were included. The mean age at diagnosis was 61.0 years (median 61.0 years), with a range of 19-104 years. Univariate analysis revealed that male gender, distant metastasis, and age ≥ 80 years as significant adverse factors for OS and CSS. These factors remained significance in the multivariate analysis. The nomogram demonstrated satisfactory discrimination, with a C-index value of 0.663 for OS and 0.654 for CSS, respectively. For both OS and CSS, the DCA curves indicated that the nomogram model performed better than other clinical variables.
Conclusion:
Older age, male gender, distant metastasis, and radiotherapy were significantly related to poor prognosis; and extent of resection did not affect survival.
