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Development of a Customized Endoscopic Dual-Diffusing Optical Fiber Probe for Pancreatic Cancer Therapy: Toward

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A new dual-diffusing optical fiber probe (DDOFP) uniformly illuminates the pancreatic duct for photodynamic therapy (PDT). This robust, clinically approved device ensures consistent light delivery for pancreatic cancer treatment.

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Area of Science:

  • Biomedical Optics
  • Surgical Instrumentation
  • Cancer Therapy

Background:

  • Optical fibers offer a novel approach for pancreatic cancer photodynamic therapy (PDT) by accessing the pancreatic duct.
  • Effective pancreatic PDT requires uniform light distribution within the duct and robust performance under surgical conditions.
  • Existing methods face challenges in achieving consistent illumination and maintaining optical properties during treatment.

Purpose of the Study:

  • To develop and characterize a dual-diffusing optical fiber probe (DDOFP) for uniform pancreatic duct illumination in clinical PDT.
  • To evaluate the DDOFP's thermomechanical stability and light transmission properties under simulated surgical conditions.

Main Methods:

  • Fabrication of a DDOFP integrated into a 19-gauge needle catheter for clinical compatibility.
  • Measurement of transmission profiles using a CCD camera and assessment of light uniformity.
  • Simulation of transmission changes in curved ducts using phantoms and evaluation of thermal stability with a thermistor probe.

Main Results:

  • The DDOFP achieved uniform light illumination (<10% intensity difference) in both front-spherical and side-cylindrical areas.
  • Consistent transmission intensity was maintained even when the DDOFP was bent to a curvature of <15 mm.
  • The probe demonstrated robustness against cracking and deformation under high-power laser delivery.

Conclusions:

  • The developed DDOFP provides superior thermomechanical properties and uniform light delivery for pancreatic PDT.
  • As the smallest clinically available optical fiber, the DDOFP is approved by the Korea Food and Drug Administration.
  • This innovation has the potential to significantly enhance the efficacy of pancreatic PDT and photothermal therapy.