Clarifying the Link Between the Blood Lactate Concentration and Cardiovascular Risk

The blood lactate value at rest (Lac_rest) is linked to cardiovascular outcomes. It is unclear whether this association holds true in younger, healthy subjects, especially as the pathophysiological connection between Lac_rest and cardiometabolic disease is not well understood. The aim of this study is clarifying the link between Lac_rest and cardiovascular risk, and to study explanatory factors for the variance of Lac_rest concerning metabolism and physical activity in a population of healthy patient-athletes. The distribution and intra-individual variability of Lac_rest was assessed based on 9051 samples. The 10-year cardiovascular risk was then approximated using the Framingham risk score in a group of 1315 samples from patient-athletes. Cross-validated linear regression was used to analyze explanatory variables for Lac_rest and 10-year cardiovascular risk. Lac_rest is weakly associated with the Framingham score. This association disappears when adjusting for blood lipids. Lac_rest is also linked to the predominant type of exercise with endurance athletes featuring a higher Lac_rest. Lac_rest does not independently predict the estimated cardiovascular risk but is associated with lipid parameters. Moreover, the intra-individual variability of Lac_rest is high in a relevant number of subjects, which does not point towards the feasibility to use Lac_rest as an individual risk factor.