[Relationship between Left Ventricle Myocardium Volume in Coronary Territories' Analysis and Fractional Flow Reserve]

Area of Science:

• Cardiology
• Medical Imaging
• Diagnostic Techniques

Background:

• Functional ischemia is crucial in diagnosing ischemic heart disease.
• Current diagnostic methods may be invasive or lack comprehensive morphological information.
• Coronary artery computed tomography (CACT) offers detailed anatomical data.

Purpose of the Study:

• To assess the feasibility of estimating functional ischemia using CACT morphological data.
• To correlate CACT-derived ischemic myocardium percentage with fractional flow reserve (FFR).
• To establish a CACT-based threshold for predicting functional ischemia.

Main Methods:

• Fifty-five patients with suspected ischemic heart disease were included.
• Ischemic myocardium percentage was calculated from CACT using coronary territories analysis (Ziostation2).
• CACT-derived percentage was compared with invasively measured FFR.

Main Results:

• A significant negative correlation (r=-0.57) was found between ischemic LV myocardium percentage and FFR.
• The median ischemic LV myocardium percentage was significantly higher in the FFR-positive group (37.1%) versus the FFR-negative group (24.8%).
• A cutoff value of 30% for ischemic LV myocardium percentage demonstrated 90.9% sensitivity and 77.3% specificity for detecting functional ischemia.

Conclusions:

• CACT analysis can estimate functional myocardial ischemia.
• An ischemic LV myocardium percentage exceeding 30% from CACT suggests the presence of functional ischemia.
• CACT-derived ischemic myocardium percentage shows potential as a non-invasive tool for diagnosing functional ischemia.