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Updated: Sep 28, 2025
08:35
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
Published on: March 17, 2015
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The TRPM8 channel as a potential therapeutic target for bladder hypersensitive disorders
1Department of Pharmacology and Toxicology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan.
Summary
Transient Receptor Potential Melastatin 8 (TRPM8) channels in the bladder are key sensors. Blocking TRPM8 may treat bladder hypersensitivity disorders like overactive bladder.
Area of Science:
- Urology
- Neuroscience
- Pharmacology
Background:
- Transient Receptor Potential (TRP) channels are crucial sensors in the lower urinary tract.
- TRP Melastatin 8 (TRPM8) channels are expressed in bladder-innervating neurons, responding to cold and chemical stimuli.
- TRPM8 channels are implicated in bladder sensory function and hypersensitivity.
Purpose of the Study:
- To review the functional role of TRPM8 channels in the lower urinary tract.
- To explore the therapeutic potential of TRPM8 antagonists for bladder disorders.
Main Methods:
- Literature review of studies on TRPM8 channel function in the lower urinary tract.
- Analysis of pharmacological investigations in rodents and humans regarding TRPM8 and bladder hypersensitivity.
Main Results:
- TRPM8 channels significantly contribute to bladder afferent sensory function.
- Evidence suggests TRPM8 channels play a role in the pathophysiology of bladder hypersensitivity.
- Rodent and human studies support TRPM8's involvement in bladder afferent hypersensitivity.
Conclusions:
- TRPM8 channels are vital for bladder sensory perception.
- TRPM8 antagonists represent a promising therapeutic strategy for bladder hypersensitive disorders.
- Targeting TRPM8 could alleviate symptoms such as urinary urgency and pain.
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