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Long-Term Outcomes in Patients with Not-Retrieval Inferior Vena Cava Filter Under Anticoagulation
Ryohei Sakai1, Shinya Fujiki1, Takeshi Kashimura1
1Department of Cardiovascular Medicine, Niigata University Graduate School of Medical and Dental Sciences.
Insights
Retrieving inferior vena cava (IVC) filters is recommended, but many remain. Long-term anticoagulation in patients with non-retrieved IVC filters can prevent deep vein thrombosis (DVT) recurrence, despite bleeding risks.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Cardiology
Background:
- Permanent inferior vena cava (IVC) filters are associated with increased deep vein thrombosis (DVT) risk.
- Guidelines recommend IVC filter retrieval, yet retrieval rates remain low in clinical practice.
- The long-term outcomes of patients with non-retrieved IVC filters on anticoagulation are not well-established.
Purpose of the Study:
- To investigate the long-term prognosis of patients with non-retrieved IVC filters.
- To evaluate the incidence of venous thromboembolism (VTE) recurrence and bleeding events in this cohort.
- To assess the effectiveness and safety of continued anticoagulation therapy in patients with non-retrieved IVC filters.
Main Methods:
- Retrospective study of 195 patients who underwent IVC filter implantation between 2006 and 2017.
- Analysis of patient data from three institutions in Niigata City.
- Inclusion of data on deaths, VTE recurrence, bleeding events, and anticoagulation status during a mean 5.0-year follow-up.
Main Results:
- A total of 158 patients (81%) had non-retrieved IVC filters, with a retrieval rate of 19.0%.
- The non-retrieved group was older and had a higher prevalence of cancer.
- During follow-up, 6 symptomatic DVT events and 13 bleeding events occurred. Cancer was the only significant prognostic risk factor for mortality.
Conclusions:
- Despite low retrieval rates, appropriate anticoagulation in patients with non-retrieved IVC filters appears effective in preventing DVT recurrence.
- Long-term anticoagulation may increase bleeding risk, but benefits in preventing VTE recurrence are evident.
- Continued anticoagulation is a viable strategy for managing patients with non-retrieved IVC filters.
Abstract:
Since permanent inferior vena cava (IVC) filters increase deep vein thrombosis (DVT), filter retrieval should be performed as possible. Despite the guideline recommendation, IVC filters are not always retrieved in clinical practice. To date, many patients with not-retrieval IVC filters have been prescribed anticoagulant therapy, but the long-term prognosis, including venous thromboembolism (VTE) and bleeding events, remains unknown. In this study, 195 patients who underwent IVC filter implantation between 2006 and 2017 at 3 institutions in Niigata City have been investigated about their deaths, VTE recurrence, and bleeding events. After peaking 2009, the number of IVC filter implantation gradually decreased. During observational period, there were 158 patients with not-retrieval IVC filters (the overall retrieval rate of 19.0%). The not-retrieval group included significantly older and more patients with cancer compared to the retrieval group. Anticoagulation therapy was continued in 88% of the not-retrieval group. During a mean follow-up of 5.0 years, 6 symptomatic DVT events associated with inadequate control of anticoagulation and 13 bleeding events were observed. A total of 52 patients died and only the presence of cancer was prognostic risk factor. Although long-term anticoagulation therapy may be associated with bleeding events, there were few recurrent VTE under optimal anticoagulation. It is anticipated that even if the IVC filter cannot be retrieved, appropriate anticoagulation is useful for prevention of DVT recurrence despite the risk of bleeding.
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