Descriptive analysis of recurrences of nasal intestinal-type adenocarcinomas after radiotherapy
Yazan Abu-Shama1, Sophie Renard2, Duc Trung Nguyen1
1Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nancy, Nancy, France.
Background:
Despite adjuvant radiotherapy, rates of recurrences of endoscopically operated nasal intestinal-type adenocarcinomas (ITAC) have not been improved in successive series. To better understand how to improve local control, we aimed to investigate the site of local recurrences of ITACs.
Methods:
Retrospective study in a reference center in sinonasal malignancies. For all patients with a local recurrence, radiotherapy plans were retrieved and compared to the delineation of local recurrences.
Results:
Of 63 patients, 54 underwent adjuvant radiotherapy of which 14 (25.9%) had a local recurrence. Eleven of them had their onset in an optimally irradiated area. Difficulty to dissect the cribriform plate and/or the lateral lamina was reported for 11 patients with local recurrences in the operative reports (p <0.0001).
Conclusions:
Most of recurrences arose in an optimally irradiated area. A close cooperation between surgeons and radiotherapists is required to define areas at risk and adapt treatment.
