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Updated: Sep 28, 2025

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Tertiary syphilis mimicking metastatic rectal cancer
Matthew J Smith1, Meydene Ong1, Abrar Maqbool1
1Department of General Surgery, Griffith Base Hospital, Griffith, New South Wales, Australia.
Journal of Surgical Case Reports
|March 31, 2022
Abstract:
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. Tertiary syphilis, a late-stage multi-visceral complication of the disease is characterized by its diversity of clinical manifestations. Here, we present the first documented case of tertiary syphilis that clinically and radiologically mimicked primary rectal cancer with hepatic metastasis.
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