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Immunotherapy in HER2-Positive Breast Cancer: A Systematic Review
Anastasios Kyriazoglou1, Maria Kaparelou1, Georgios Goumas2
1Department of Clinical Therapeutics, General Hospital Alexandra, Athens, Greece.
Introduction:
The clinical outcome of HER2-positive breast cancer patients changed with the use of anti-Her therapies, though it still remains an aggressive and fatal disease. Implementation of immune checkpoint inhibitors in HER2-positive Breast cancer is a concept supported by the reported biological and preclinical data.
Methods:
We conducted a systematic review of the current literature involving immune checkpoint inhibitors alone or in combination with targeted therapies or chemotherapy finalized or running in HER2-positive breast cancer.
Results:
Twelve clinical trials and 2 case reports were identified in our study.
Conclusion:
The reported clinical trials highlight that checkpoint inhibition seems to be promising in metastatic, neoadjuvant, and adjuvant settings of HER2-positive breast cancer.
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