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Protective Effects of Bromelain against Cadmium-Induced Pulmonary Intoxication in Rats: A Histopathologic and
S Rafiei-Asl1, Gh Khadjeh1, S M Jalali1
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Archives of Razi Institute
|March 31, 2022
Summary
Bromelain, derived from pineapple, shows potential in mitigating lung damage from cadmium exposure. While not a complete cure, it significantly reduces inflammatory cells and improves histopathological scores in rats.
Area of Science:
- Toxicology
- Pharmacology
- Pulmonary Medicine
Background:
- Cadmium exposure poses significant risks to pulmonary health.
- Bromelain, a pineapple enzyme, exhibits anti-inflammatory properties.
- Understanding bromelain's protective effects against cadmium-induced lung injury is crucial.
Purpose of the Study:
- To evaluate the protective effects of bromelain against acute cadmium intratracheal exposure.
- To assess the impact of bromelain on bronchopulmonary cytologic and histopathologic changes induced by cadmium.
- To compare bromelain's efficacy with celecoxib in mitigating cadmium toxicity.
Main Methods:
- Wistar rats were divided into 11 groups, receiving cadmium chloride (CdCl2) intratracheally.
- Bromelain (20 and 40 mg/kg) or celecoxib (25 mg/kg) were administered orally before and after CdCl2 exposure.
- Cytologic analysis of bronchoalveolar lavage fluid and histopathologic examination of lung tissues were performed.
Main Results:
- Cadmium exposure significantly increased total cell count, epithelial cells, neutrophils, and eosinophils in bronchoalveolar lavage fluid.
- Bromelain treatment, at both low and high doses, significantly reduced neutrophil counts.
- Bromelain administration, particularly at low doses, led to a significant decrease in histopathologic scores for pneumonia and cellular infiltration.
Conclusions:
- Bromelain demonstrates potential therapeutic benefits in managing pulmonary complications associated with cadmium intoxication.
- Bromelain may help improve cytologic and histopathologic outcomes following cadmium-induced lung injury.
- Further research is warranted to fully elucidate bromelain's role in preventing and treating lung damage from environmental toxins.
