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Tissue adhesives and intestinal anastomosis
Annales Chirurgiae Et Gynaecologiae
|January 1, 1986
Summary
Fibrin adhesives show promise for improving intestinal anastomoses, potentially reducing mortality rates. However, further randomized trials are needed to confirm these findings for surgical applications.
Area of Science:
- Surgical innovation
- Biomaterials in surgery
Background:
- Intestinal anastomoses are crucial surgical procedures.
- Tissue adhesives offer potential for enhancing anastomosis.
- Fibrin and cyanoacrylate adhesives have been explored.
Purpose of the Study:
- To review the literature on tissue adhesives for intestinal anastomoses.
- To evaluate the efficacy and safety of fibrin adhesives.
- To assess the viability of cyanoacrylate adhesives.
Main Methods:
- Literature review of studies on tissue adhesives in intestinal anastomosis.
- Analysis of experimental and clinical data on fibrin adhesive sealing.
- Comparison of cyanoacrylate adhesives with conventional methods.
Main Results:
- Fibrin adhesive is physiological, non-toxic, and non-allergenic.
- Fibrin adhesive sealing may reduce postoperative mortality.
- Prospective, randomized trials are lacking for fibrin adhesive sealing.
- Cyanoacrylate adhesives have proven inferior to conventional anastomosis.
Conclusions:
- Fibrin adhesive is the preferred tissue adhesive for intestinal anastomoses.
- Further research, including randomized trials, is needed to validate fibrin adhesive benefits.
- Cyanoacrylate adhesives are not recommended for intestinal anastomoses.