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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

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Published on: March 30, 2018

MSC therapy in livestock models.

Ellen M Harness¹, Nuradilla Binti Mohamad-Fauzi^2,3, James D Murray^1,4

¹Department of Animal Science, University of California, Davis, One Shields Ave., Davis, CA 95616, USA.

Translational Animal Science

|March 31, 2022

Summary

This summary is machine-generated.

Livestock models offer significant value for studying mesenchymal stem cell (MSC) therapies, advancing regenerative medicine and improving both human and animal health. Their physiological similarities to humans make them ideal for translational research.

Keywords:

agriculture dual-purpose model in vivo model livestock mesenchymal stem/stromal cell regenerative therapy

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Area of Science:

Regenerative Medicine
Cell Therapy
Animal Models

Background:

Mesenchymal stem cells (MSCs) possess diverse therapeutic properties, including tissue regeneration, immunomodulation, and antimicrobial effects.
MSC-based therapy shows promise for various clinical conditions, necessitating further research into their physiological functions and benefits.

Purpose of the Study:

To highlight the utility of livestock as in vivo models for testing mesenchymal stem cell (MSC) therapies.
To underscore the advantages of agricultural animal models in biomedical research for human and animal health applications.

Main Methods:

Evaluating the suitability of agricultural animal models (pigs, cattle, sheep, goats) for in vivo research.
Comparing the efficacy of livestock models to small animal models in preclinical research.

Main Results:

Livestock models share structural and functional similarities with humans, making them superior to small animal models for certain research areas.
Investigating MSC therapy in livestock for conditions like wound healing, bone regeneration, osteoarthritis, ischemic injury, and mastitis.

Conclusions:

Livestock models are valuable for advancing MSC-based therapies and exosome-based treatments, bridging the gap between research and clinical practice.
Utilizing livestock models offers dual benefits for agricultural economic gains and improved animal health, alongside human health advancements.