Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Potential targets for antiviral chemotherapy.

W H Prusoff, T S Lin, M Zucker

    Antiviral Research
    |October 1, 1986
    PubMed
    Summary

    Discovering new antiviral agents relies on understanding viral replication and host interactions. This review explores potential viral targets and strategies for developing selective antiviral drugs.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Platelet factor XI: intracellular localization and mRNA splicing following platelet activation.

    Blood cells, molecules & diseases·2017
    Same author

    An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase.

    Journal of thrombosis and haemostasis : JTH·2016
    Same author

    miR-155 expression is associated with chemoimmunotherapy outcome and is modulated by Bruton's tyrosine kinase inhibition with Ibrutinib.

    Leukemia·2014
    Same author

    Abnormal plasma clot structure and stability distinguish bleeding risk in patients with severe factor XI deficiency.

    Journal of thrombosis and haemostasis : JTH·2014
    Same author

    Cardiac autonomic function and insulin resistance for the development of hypertension: a six-year epidemiological follow-up study.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2013
    Same author

    Type I mutation in the F11 gene is a third ancestral mutation which causes factor XI deficiency in Ashkenazi Jews.

    Journal of thrombosis and haemostasis : JTH·2013

    Area of Science:

    • Virology
    • Medicinal Chemistry
    • Drug Discovery

    Background:

    • Historically, serendipity and random screening yielded effective antiviral agents.
    • Advancements in understanding viral replication and host interactions reveal existing and novel drug targets.
    • Molecular insights guide the development of antivirals with enhanced selectivity.

    Purpose of the Study:

    • To review potential viral targets susceptible to therapeutic intervention.
    • To present various approaches for the development of novel antiviral agents.
    • To highlight the role of molecular understanding in antiviral drug design.

    Main Methods:

    • Literature review of viral targets and antiviral development strategies.
    • Analysis of biochemical pathways in viral replication.
    • Exploration of virus-host interrelationships.

    Main Results:

    • Identification of multiple viral targets amenable to antiviral attack.
    • Overview of diverse strategies for synthesizing selective antiviral compounds.
    • Emphasis on the transition from random screening to rational drug design.

    Conclusions:

    • Molecular understanding is crucial for developing targeted antiviral therapies.
    • Exploring viral targets and development approaches can lead to effective antiviral agents.
    • Future antiviral drug development hinges on precise molecular targeting.

    Related Experiment Videos