Related Experiment Video For anticancer
Updated: Sep 28, 2025

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
Published on: June 16, 2023
Citrate transporter inhibitors: possible new anticancer agents
Shivaputra A Patil1, June A Mayor2, Ronald S Kaplan2,3
1Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine & Science, North Chicago, IL 60064-3095, USA.
Abstract:
The culmination of 80+ years of cancer research implicates the aberrant metabolism in tumor cells as a root cause of pathogenesis. Citrate is an essential molecule in intermediary metabolism, and its amplified availability to critical pathways in cancer cells via citrate transporters confers a high rate of cancer cell growth and proliferation. Inhibiting the plasma membrane and mitochondrial citrate transporters - whether individually, in combination, or partnered with complementary metabolic targets - in order to combat cancer may prove to be a consequential chemotherapeutic strategy. This review aims to summarize the use of different classes of citrate transporter inhibitors for anticancer activity, either individually or as part of a cocktail.
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