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Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Related Experiment Video

Updated: Sep 28, 2025

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

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Assessing Safety Without Animal Testing: The Road Ahead

George P Daston¹, Catherine Mahony², Russell S Thomas³

¹The Procter & Gamble Company, Cincinnati, Ohio 45040, USA.

Toxicological Sciences : an Official Journal of the Society of Toxicology

|March 31, 2022

Summary

No abstract available in PubMed .

Keywords:

computational toxicology new approach methods predictive toxicology

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