Related Experiment Video

Updated: Sep 28, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.1K

Phytochemicals targeting NAFLD through modulating the dual function of forkhead box O1 (FOXO1) transcription factor

Usman Sabir1, Hafiz Muhammad Irfan2, Alamgeer3

  • 1Department of Pharmacology, College of Pharmacy, University of Sargodha, Sargodha, Pakistan.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|March 31, 2022
PubMed

Insights

Natural compounds targeting the FOXO1 transcription factor show promise for treating obesity-linked non-alcoholic fatty liver disease (NAFLD). These phytochemicals help regulate lipid metabolism and restore nutrient balance, offering potential therapeutic benefits.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Hepatology

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is a growing health concern linked to obesity and metabolic disorders.
  • The forkhead box O1 (FOXO1) transcription factor plays a complex role in lipid accumulation and insulin resistance in NAFLD.
  • Dysregulation of FOXO1 disrupts cellular nutrient homeostasis, contributing to NAFLD progression.

Purpose of the Study:

  • To review and evaluate phytochemicals that target FOXO1 and its downstream pathways for NAFLD treatment.
  • To identify natural compounds with therapeutic potential for NAFLD and related metabolic conditions.
  • To explore the mechanisms by which natural compounds modulate FOXO1 activity in the context of NAFLD.

Main Methods:

  • Systematic literature search using various search engines.
  • Analysis of studies focusing on phytochemicals targeting FOXO1 and its associated cellular pathways.
  • Evaluation of the impact of natural compounds on lipid metabolism, inflammation, and oxidative stress in NAFLD models.

Main Results:

  • Polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins demonstrate the ability to modulate FOXO1 signaling.
  • These phytochemicals can mitigate lipid accumulation, inflammation, and oxidative stress in NAFLD.
  • Natural compounds effectively target FOXO1, SREBP1c, and PPARγ signaling pathways.

Conclusions:

  • FOXO1 is a viable therapeutic target for novel drugs derived from natural sources for NAFLD and obesity.
  • Phytochemicals offer a promising strategy for managing NAFLD by modulating FOXO1-mediated cellular processes.
  • Natural compounds hold potential as therapeutic agents for NAFLD and associated metabolic complications.
Keywords:
FlavonoidsForkhead box O1 transcription factorNonalcoholic fatty liver diseasePhytochemicalsPolyphenols

More Related Videos

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model08:20

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

2.0K
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

16.2K

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.9K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
54
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.7K