Value of deep learning reconstruction at ultra-low-dose CT for evaluation of urolithiasis

To determine the diagnostic accuracy and image quality of ultra-low-dose computed tomography (ULDCT) with deep learning reconstruction (DLR) to evaluate patients with suspected urolithiasis, compared with ULDCT with hybrid iterative reconstruction (HIR) by using low-dose CT (LDCT) with HIR as the reference standard.

Patients with suspected urolithiasis were prospectively enrolled and underwent abdominopelvic LDCT, followed by ULDCT if any urinary stone was observed. Radiation exposure, stone characteristics, image noise, signal-to-noise ratio (SNR), and subjective image quality on a 5-point Likert scale were evaluated and compared.

The average effective radiation dose of ULDCT was significantly lower than that of LDCT (1.28 ± 0.34 vs. 5.49 ± 1.00 mSv, p < 0.001). According to the reference standard (LDCT-HIR), 148 urinary stones were observed in 85.0% (51/60) of patients. ULDCT-DLR detected 143 stones with a rate of 96.6%, and ULDCT-HIR detected 142 stones with a rate of 95.9%. The urinary stones that were not observed with ULDCT-DLR or ULDCT-HIR were renal calculi smaller than 3 mm. There were no significant differences in the detection of clinically significant calculi (≥ 3 mm) or stone size estimation among ULDCT-DLR, ULDCT-HIR, and LDCT-HIR. The image quality of ULDCT-DLR was better than that of ULDCT-HIR and LDCT-HIR with lower image noise, higher SNR, and higher average subjective score.

ULDCT-DLR performed comparably to LDCT-HIR in urinary stone detection and size estimation with better image quality and decreased radiation exposure. ULDCT-DLR may have potential to be considered the first-line choice to evaluate urolithiasis in practice.

• Ultra-low-dose computed tomography (ULDCT) has been investigated for diagnosis of urolithiasis, but stone evaluation may be adversely impacted by compromised image quality. • This study evaluated the value of novel deep learning reconstruction (DLR) at ULDCT by comparing the stone evaluation and image quality of ULDCT-DLR to the reference standard of low-dose CT (LDCT) with hybrid iterative reconstruction (HIR). • ULDCT-DLR performed comparably to LDCT-HIR in urinary stone detection and size estimation with better image quality and reduced radiation exposure.