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06:47
A Murine Model of Vertical Sleeve Gastrectomy
Published on: December 18, 2017
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Glucose variability and predicted cardiovascular risk after gastrectomy.
Jun Shibamoto1, Takeshi Kubota2, Takuma Ohashi1
1Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Surgery Today
|March 31, 2022
Summary
Glycemic variability after gastric cancer surgery correlates with cardiovascular risk. Patients with diabetes or total gastrectomy show higher glucose variability, necessitating tailored long-term management to prevent cardiovascular events.
Area of Science:
- Oncology
- Endocrinology
- Cardiology
Background:
- Gastric cancer surgery (gastrectomy) can impact metabolic health.
- Post-surgical glycemic dysregulation is a potential concern for long-term patient outcomes.
- Cardiovascular disease is a significant comorbidity in cancer survivors.
Purpose of the Study:
- To explore the relationship between glycemic trends and cardiovascular risk in patients following gastrectomy for gastric cancer.
- To identify specific glycemic patterns associated with increased cardiovascular risk.
Main Methods:
- Continuous glucose monitoring (CGM) was used to assess postoperative glucose levels in 105 gastric cancer patients.
- Cardiovascular risk was evaluated using established scores: Framingham stroke risk profile score (FSRPS), Framingham risk score (FRS), and Suita score.
- Statistical analyses were performed to correlate glycemic variability metrics (e.g., standard deviation) with cardiovascular risk scores.
Main Results:
- Significant differences in glucose standard deviation (SD) were observed between high and low cardiovascular risk groups (FSRPS, FRS, Suita score).
- Elevated glucose SD was noted in patients with diabetes mellitus (DM) and those who underwent total gastrectomy (TG).
- Glycemic variability (SD) increased significantly from 1 month to 1 year post-gastrectomy.
Conclusions:
- Glycemic trends after gastrectomy are linked to cardiovascular risk.
- Patients with DM and those undergoing TG require closer monitoring for glycemic variability.
- Long-term follow-up and individualized therapeutic strategies focusing on glycemic control are recommended to mitigate cardiovascular event risk.
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