Related Experiment Video
Updated: Sep 28, 2025
08:39
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Published on: November 7, 2020
8.0K
[Neurological disorders in liver transplantation]
Hatice Yuksel1, Osman Aydin2, Derya Ari3
1Department of Neurology, Ankara City Hospital, Ankara, Turkey.
Ideggyogyaszati Szemle
|March 31, 2022
Summary
Neurological disorders are common after liver transplantation, with hepatic encephalopathy and altered mental states significantly increasing mortality risk. Early identification and management are crucial for improving patient outcomes.
Area of Science:
- Hepatology
- Neurology
- Transplantation Medicine
Background:
- Liver transplantation is the sole cure for end-stage liver failure.
- Neurological complications are more prevalent in liver transplant recipients than other solid organ transplantations.
Purpose of the Study:
- To identify neurological disorders in liver transplant patients.
- To determine which neurological disorders impact patient mortality.
Main Methods:
- 185 patients were studied (105 with and 80 without neurological disorders).
- Patient data was collected preoperatively, and during early and late postoperative periods.
- Analysis included demographic, laboratory, radiological, and clinical data.
Main Results:
- Neurological disorders were detected in 28.1% preoperatively, 24.3% early postoperatively, and 22.7% late postoperatively.
- Hepatic encephalopathy and altered mental state were common, significantly increasing mortality (p=0.019 and p=0.001).
- Seizures (53.8% mortality) and hepatic encephalopathy are independent risk factors for mortality.
Conclusions:
- A wide spectrum of neurological disorders occurs in liver transplant patients.
- Serious neurological conditions like hepatic encephalopathy and seizures are linked to high morbidity and mortality.
- Hepatic encephalopathy should be a prioritization criterion for liver transplantation to improve outcomes.
Related Concept Videos
01:28Disorders of the Nervous Tissue
1.8K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.8K
01:24Tissue Transplantation
542
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
542
01:28Kidney Transplant I: Introduction
67
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
67
01:28Esophageal Varices-II: Clinical Features and Management
162
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
162
01:26Kidney Transplant II: Surgical Procedure
82
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
82
01:16Kidney Transplant III: Nursing Management
90
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
90