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Related Experiment Video

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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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Association between trace elements and preeclampsia: A retrospective cohort study.

Ying Chen¹, Qi Xin Ou¹, Yu Chen²

¹Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong, China.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)

|March 31, 2022

Summary

Higher mid-term pregnancy blood magnesium (Mg) and copper (Cu) levels are linked to a reduced risk of preeclampsia, a major cause of maternal mortality. This study explored trace element associations in early pregnancy.

Keywords:

Calcium Copper Iron Magnesium Preeclampsia Trace elements

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Published on: July 30, 2016

Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Nutritional Biochemistry

Background:

Preeclampsia is a leading cause of maternal and perinatal mortality globally.
Existing research on trace elements and preeclampsia shows varied results, with limited data on early to mid-term pregnancy.
Understanding these associations is crucial for early detection and prevention strategies.

Purpose of the Study:

To investigate the association between trace element levels in mid-term pregnancy and the risk of developing preeclampsia.
To explore potential protective roles of specific trace elements against preeclampsia.
To provide evidence for nutritional interventions in pregnancy.

Main Methods:

A retrospective cohort study involving 2186 participants in Guangdong Province, China.
Maternal whole blood trace element levels (Mg, Cu, Zn, Fe, Ca) were measured between 12-27 weeks gestation using flame atomic absorption spectrometry.
Multivariable logistic regression analysis was employed to determine odds ratios (OR) and 95% confidence intervals (CI) for preeclampsia risk.

Main Results:

Higher blood magnesium (Mg) levels were associated with a reduced risk of preeclampsia, particularly in the highest quintile (OR=0.29; 95% CI: 0.10, 0.85).
Increased blood copper (Cu) levels showed a trend towards lower preeclampsia risk (OR=0.89 per µmol/L increment; 95% CI: 0.78, 1.02), with significant reductions observed in higher quintiles.
No significant associations were found between zinc (Zn), iron (Fe), or calcium (Ca) levels and preeclampsia risk.

Conclusions:

Elevated blood magnesium and copper levels during mid-term pregnancy are associated with a decreased risk of preeclampsia.
These findings suggest potential benefits of maintaining adequate Mg and Cu status in pregnancy.
Further research is warranted to confirm these associations and explore clinical applications.