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Dysregulation of miR-411 in cancer: Causative factor for pathogenesis, diagnosis and prognosis

Mengsha Zou1, Jinze Shen2, Yuchen Wu3

  • 1Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, Zhejiang, China; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 31, 2022
PubMed

Insights

MicroRNA-411 (miR-411) dysregulation impacts cancer progression and signaling pathways. Understanding its role offers potential for cancer diagnosis, prognosis, and targeted therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) regulate a significant portion of human gene expression.
  • miR-411, a non-coding RNA, is implicated in various cellular processes.

Purpose of the Study:

  • To analyze current research gaps and challenges in miR-411 studies.
  • To explore the potential of miR-411 in cancer diagnosis, prognosis, and treatment.

Main Methods:

  • Review and analysis of existing literature on miR-411.
  • Examination of miR-411's regulatory roles in cancer cell behavior.
  • Investigation of signaling pathways influenced by miR-411.

Main Results:

  • Aberrant miR-411 expression is observed in multiple cancer types.
  • miR-411 influences cancer cell proliferation, invasion, migration, and apoptosis.
  • miR-411 targets multiple genes, impacting key signaling pathways like MAPK, PI3K/AKT/mTOR, and Wnt/β-catenin.

Conclusions:

  • miR-411's dysregulation is linked to cancer development and progression.
  • miR-411 expression correlates with cancer diagnosis, prognosis, and drug sensitivity.
  • miR-411 holds promise as a biomarker and therapeutic target in oncology.
Keywords:
DiagnosisMiR-411PathwayPrognosisTarget geneTumor

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