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Updated: Sep 28, 2025
09:44
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
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[Acute-on-chronic liver failure: definition, diagnosis, and pathogenesis]
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Summary
Acute-on-chronic liver failure (ACLF) is a severe syndrome with high mortality. This review covers ACLF definitions, prediction models, and pathogenesis for better understanding and management.
Area of Science:
- Hepatology
- Internal Medicine
- Critical Care Medicine
Background:
- Acute-on-chronic liver failure (ACLF) represents a critical decompensation of chronic liver disease.
- It is characterized by rapid deterioration of liver function and multi-organ failure.
- ACLF carries a very high short-term mortality rate, ranging from 50% to 90%.
Purpose of the Study:
- To provide a comprehensive overview of the current understanding of ACLF.
- To summarize established definitions and diagnostic criteria for ACLF.
- To review early-warning prediction models and the underlying pathogenesis of ACLF.
Main Methods:
- Literature review of existing studies on ACLF.
- Synthesis of information on definitions, diagnostic criteria, and prediction models.
- Analysis of current research on the pathogenesis of ACLF.
Main Results:
- ACLF is defined by acute liver dysfunction superimposed on chronic liver disease.
- Various prediction models aim for early identification of high-risk patients.
- Pathogenesis involves complex interactions leading to organ failure.
Conclusions:
- A clear understanding of ACLF definitions and criteria is crucial for timely diagnosis.
- Early-warning systems can potentially improve patient outcomes.
- Further research into ACLF pathogenesis is needed to develop targeted therapies.
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