[Experimental study of the effect of captopril on pain reactions]

The experiments on the electrical stimulation of the isolated guinea-pig ileum have shown that captopril (10(-6)-10(-4) g/ml) caused dose-dependent inhibition of the organ contractions, abrogated by naloxone. In mice, the drug in the doses of 0.1 to 0.5 mg/kg administered subcutaneously had hyperalgesic effect and, with the dose increase (1-25 mg/kg), progressively attenuated the degree of nociceptive reactions caused by thermal and chemical stimulation. When kininogen accumulations were depleted due to the injection of kininogenase activator-cellulose sulfate, captopril in all the doses studied had an analgetic effect, with it reduced by naloxone. The data obtained show that dipeptidyl-carboxypeptidase inhibition by captopril can affect the degree of nociceptive reactions caused by various nociceptive stimuli.