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MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

Xiaocui Liu1, Shang Zhao2, Hongshu Sui1

  • 1Department of Histology and Embryology, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, China.

Frontiers in Oncology
|April 1, 2022
PubMed

Insights

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), regulate myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME). Understanding these interactions offers new avenues for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Myeloid-derived suppressor cells (MDSCs) are crucial immunosuppressive cells in the tumor microenvironment (TME), driving cancer progression.
  • Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are key regulators of gene expression.
  • Emerging evidence highlights the role of miRNAs and lncRNAs in modulating MDSCs within the TME.

Purpose of the Study:

  • To summarize the regulatory roles of miRNAs and lncRNAs in the differentiation, expansion, and immunosuppressive functions of tumor-associated MDSCs.
  • To focus on the mechanisms by which exosomal miRNAs and lncRNAs influence tumor MDSCs.
  • To discuss the intricate interactions between miRNAs and lncRNAs in modulating tumor MDSCs.

Main Methods:

  • Literature review and synthesis of existing research on ncRNAs and MDSCs.
  • Analysis of regulatory mechanisms of miRNAs and lncRNAs in MDSC biology.
  • Exploration of exosomal transfer and intercellular communication involving ncRNAs and MDSCs.

Main Results:

  • MiRNAs and lncRNAs significantly impact MDSC differentiation, expansion, and immunosuppressive activity in the TME.
  • Exosomal miRNAs and lncRNAs act as critical mediators in intercellular communication, influencing tumor MDSC behavior.
  • The interplay between different types of ncRNAs collectively shapes the function of tumor MDSCs.

Conclusions:

  • MiRNAs and lncRNAs are pivotal in regulating tumor MDSCs and represent promising targets for cancer immunotherapy.
  • Targeting exosomal ncRNAs offers a potential strategy to disrupt MDSC-mediated immunosuppression.
  • Further investigation into the complex interactions of ncRNAs is essential for developing novel cancer therapeutics.
Keywords:
lncRNAsmicroRNAsmyeloid-derived suppressor cellsnetworkstumor microenvionment

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