Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

770
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
770

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current practice patterns among Indian neurologists in the Evaluation and management of Normal Pressure Hydrocephalus: A nationwide cross-sectional survey.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Bridging the global Parkinson's divide: Technology as a structural solution for equitable and brain health-integrated care.

Journal of Parkinson's disease·2026
Same author

Myoclonus and Gaze Palsy in Childhood-Onset SQSTM1-Related Neurodegeneration.

Journal of movement disorders·2026
Same author

Whole-genome sequencing of 197 cases with Parkinson's disease reveals novel pathogenic variants in the Indian population.

NPJ Parkinson's disease·2026
Same author

TBC1D2B-related Neurodevelopmental Disorder with Gingival Overgrowth and Movement Disorders: A Case Series and Literature Review.

Journal of movement disorders·2026
Same author

Machine Learning Aided Kinematic Profiling of Reaching Movements Separates Spinocerebellar Ataxia type 12 and Essential Tremor.

Cerebellum (London, England)·2026

Related Experiment Video

Updated: Sep 28, 2025

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
08:56

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

Published on: November 7, 2014

14.0K

Semantic Fluency Predicts Gait Velocity in PSP.

Koustav Chatterjee1, Supriyo Choudhury1, Ummatul Siddique1

  • 1Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, West Bengal, India.

Annals of Indian Academy of Neurology
|April 1, 2022
PubMed
Summary

Gait variability in progressive supranuclear palsy (PSP) worsens with cognitive decline, potentially increasing fall risk. Specific cognitive tests can predict gait velocity in PSP patients.

Keywords:
Cognitive functiongaitinitiation/perseverationprogressive supranuclear palsy

More Related Videos

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.1K
Lower-Limb Biomechanical Characteristics Associated with Unplanned Gait Termination Under Different Walking Speeds
05:52

Lower-Limb Biomechanical Characteristics Associated with Unplanned Gait Termination Under Different Walking Speeds

Published on: August 25, 2020

4.7K

Related Experiment Videos

Last Updated: Sep 28, 2025

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
08:56

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

Published on: November 7, 2014

14.0K
Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.1K
Lower-Limb Biomechanical Characteristics Associated with Unplanned Gait Termination Under Different Walking Speeds
05:52

Lower-Limb Biomechanical Characteristics Associated with Unplanned Gait Termination Under Different Walking Speeds

Published on: August 25, 2020

4.7K

Area of Science:

  • Neuroscience
  • Gerontology
  • Movement Disorders

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease impacting gait and cognition.
  • The precise relationship between specific gait characteristics and cognitive function in PSP remains unclear.

Purpose of the Study:

  • To investigate the link between gait parameters and cognitive function in PSP patients.
  • To explore this relationship across different PSP variants.

Main Methods:

  • Cross-sectional study design.
  • Quantitative gait analysis using an electronic walkway (GAITRite®).
  • Cognitive function assessed using Dementia Rating Scale-2.

Main Results:

  • Gait variability was significantly impaired in PSP patients with severe cognitive impairment.
  • Initiation/perseveration (I/P) cognitive function predicted gait velocity (β = 2.39, P < 0.001).

Conclusions:

  • Cognitive severity influences gait variability, potentially contributing to falls in PSP.
  • Semantic fluency tasks within I/P function may predict gait velocity.
  • Frontal lobe dysfunction likely underlies the observed gait impairments in PSP.