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Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

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Viral Vector Vaccines Against ASF: Problems and Prospectives.

Rustam Kh Ravilov¹, Albert A Rizvanov^1,2, Danil N Mingaleev¹

¹Kazan State Academy of Veterinary Medicine named after N. E. Bauman, Kazan, Russia.

Frontiers in Veterinary Science

|April 1, 2022

Summary

African swine fever (ASF) is a deadly pig virus causing significant economic damage. Viral vector vaccines show promise for faster, cheaper ASF vaccine development by delivering targeted viral genes.

Keywords:

African swine fever disease control domestic pigs vaccine viral vectors

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Area of Science:

Veterinary Virology
Immunology
Vaccine Development

Background:

African swine fever (ASF) is a highly contagious viral disease in pigs.
ASF causes up to 100% mortality and substantial economic losses globally.
Current vaccine development for ASF is ongoing.

Purpose of the Study:

To review the use of viral vectors for ASF vaccine development.
To assess the safety and efficacy of viral vector-based ASF vaccines.
To discuss the potential for modulating immune responses against ASF.

Main Methods:

Review of studies utilizing viral vectors to deliver ASF virus genes.
Analysis of data on viral vector safety and immunogenicity.
Evaluation of protection conferred by experimental vaccines against virulent ASF strains.

Main Results:

Various viral vectors have been tested as carriers for ASF immunogens.
Viral vectors offer a potentially economical and time-efficient vaccine production method.
Modulating immune responses through gene selection is feasible.

Conclusions:

Viral vector technology presents a promising avenue for ASF vaccine development.
Further research is needed to optimize viral vectors for effective ASF immunization.
Successful viral vector vaccines could mitigate the economic impact of ASF.