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Severe Cholestatic Hepatitis Secondary to SARS-CoV-2
Christopher R Lindholm1, Xiaofei Zhang2, Erin K Spengler1
1Division of Gastroenterology and Hepatology, University of Wisconsin-Madison, Madison, WA.
ACG Case Reports Journal
|April 1, 2022
Summary
Severe cholestatic hepatitis and bile duct injury are rare but serious complications of coronavirus disease 2019 (COVID-19). This case highlights the need for greater awareness of these potential liver injuries in COVID-19 patients.
Area of Science:
- Hepatology
- Virology
- Pathology
Background:
- Coronavirus disease 2019 (COVID-19) frequently causes liver injury, predominantly mild hepatocellular damage.
- Cholestatic liver injury is an uncommon manifestation of COVID-19, usually presenting mildly.
Observation:
- A 70-year-old woman with severe COVID-19 developed severe cholestatic hepatitis.
- The patient had no prior history of liver disease.
Findings:
- Liver biopsy revealed significant bile duct injury, a rare finding in COVID-19 patients.
- This severe cholestatic hepatitis and bile duct injury represent an unusual COVID-19 complication.
Implications:
- Severe cholestatic hepatitis due to COVID-19 can be progressive and may necessitate liver transplantation.
- Increased clinical awareness of severe cholestatic injury and bile duct injury in COVID-19 is crucial for timely management.
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